Super Bowl – The Buffalo Bills first round pick was Sammy Watkins.
From Mike Mayock, “You have a young quarterback in EJ Manuel; a talented kid. Now they want to surround him with a weapon, and they went and got the premier wide receiver in this draft.”
| Round | Pick | School | Tickets |
| 1 | Sammy Watkins | Clemson | Buy Buffalo Bills tickets |
| 2 | Cyrus Kouandjio | Alabama | Buy Buffalo Bills tickets |
| 3 | Preston Brown | Louisville | Buy Buffalo Bills tickets |
| 4 | Ross Cockrell | Duke | Buy Buffalo Bills tickets |
| 5 | Cyril Richardson | Baylor | Buy Buffalo Bills tickets |
| 7 | Randell Johnson | Florida Atlantic | Buy Buffalo Bills tickets |
| 7 | Seantrel Henderson | Miami | Buy Buffalo Bills tickets |
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